Protein profiling in serum after traumatic brain injury in rats reveals potential injury markers

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Protein profiling in serum after traumatic brain injury in rats reveals potential injury markers

INTRODUCTION The serum proteome following traumatic brain injury (TBI) could provide information for outcome prediction and injury monitoring. The aim with this affinity proteomic study was to identify serum proteins over time and between normoxic and hypoxic conditions in focal TBI. MATERIAL AND METHODS Sprague Dawley rats (n=73) received a 3mm deep controlled cortical impact ("severe injury...

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Microglia is one of the first innate immune components. These cells account about 5 to 10% of the entire adult brain cells and are activated by trauma. Complex-mediated inflammatory responses occur through cellular and molecular events during and after the traumatic brain injury (TBI). In-lesion area astrocytes, microglia, and damaged neurons begin to secrete cytokines and chemokines. Microglia...

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ژورنال

عنوان ژورنال: Behavioural Brain Research

سال: 2018

ISSN: 0166-4328

DOI: 10.1016/j.bbr.2016.08.058